Indomethacin is a strong NSAID doctors turn to for painful inflammation. It works well for conditions like gout flares, certain arthritis types, and painful tendon or joint issues. Because it’s potent, you get good relief—but you also need to watch for side effects and drug interactions.
Typical doses are 25–50 mg two or three times a day for adults, but your doctor will pick the dose based on your condition and health. Always follow the prescription. Take indomethacin with food to cut stomach upset. Use the lowest effective dose for the shortest time possible.
Don’t mix indomethacin with other NSAIDs (like ibuprofen or naproxen). That raises the risk of bleeding and stomach ulcers without extra benefit. If you take blood thinners (warfarin, DOACs), certain antidepressants (SSRIs), or lithium, talk to your prescriber—interactions can be serious.
Common side effects: stomach pain, heartburn, headache, dizziness, and fluid retention. More serious but less common problems include stomach ulcers or bleeding, kidney damage, high blood pressure, and heart issues. If you notice black or bloody stools, severe belly pain, chest pain, sudden shortness of breath, or swelling that’s new and rapid, seek urgent care.
Avoid indomethacin if you have active stomach ulcers, recent heart surgery, severe heart failure, or advanced kidney disease unless a specialist advises otherwise. Pregnant people should not use indomethacin in the third trimester because it can harm the baby’s circulation.
Labs: if you’ll be on indomethacin regularly, your doctor may check kidney function, liver tests, and blood pressure. If you have asthma, indomethacin can sometimes trigger bronchospasm—report new wheeze or breathing trouble.
Alternatives include milder NSAIDs like ibuprofen or naproxen, topical NSAIDs, acetaminophen for pain without inflammation, or disease-specific drugs. For gout attacks, colchicine is another option—see our colchicine guide for safe buying and use tips.
Buying and prescriptions: indomethacin requires a prescription in most places. If you buy meds online, use a licensed pharmacy that asks for a prescription. Avoid sites that sell without one or offer suspiciously low prices—those meds may be counterfeit or unsafe.
Bottom line: indomethacin can be very effective when used correctly. Keep doses low, watch for stomach and heart symptoms, and tell your clinician about all medicines you take. Ask for clear follow-up plans and read any pharmacy handouts—small precautions prevent big problems.
Dive into how indomethacin works for chronic pain, when other NSAIDs just can't cut it. Find practical tips on dosing, safety, monitoring, and its unique edge.