Aripiprazole is an antipsychotic many doctors use for schizophrenia, bipolar disorder, and as an add-on for major depression. It can also help irritability in autism. People like it because, for many, it causes less drowsiness and weight gain than older antipsychotics. Still, it isn’t free of side effects or risks, so you should know the basics before starting or changing treatment.
Doctors prescribe aripiprazole in pills, an oral solution, and long-acting injections. Typical tablet doses range from low (2–5 mg) up to 30 mg daily for adults, depending on the condition and response. As an injection, it can be given monthly by a healthcare professional — useful if daily pills are missed.
It works differently from many other antipsychotics. Instead of just blocking dopamine, it partially stimulates certain receptors. That can mean fewer movement side effects for some people, but it also brings unique effects like restlessness or akathisia (a need to move).
Common side effects include restlessness or pacing, insomnia, nausea, constipation, and anxiety. Some people notice weight gain or changes in appetite and blood sugar — so doctors usually check weight, fasting glucose, and lipids before and during treatment.
Serious but less common risks include movement disorders (like tardive dyskinesia), neuroleptic malignant syndrome (a rare, life-threatening reaction), and increased risk of death in older adults with dementia-related psychosis. If you or a caregiver see sudden stiffness, very high fever, confusing changes in behavior, or uncontrolled movements, get medical help fast.
There’s a warning about suicidal thoughts in younger people starting antidepressants or antipsychotics. Families should watch mood and behavior closely, especially early on or after dose changes.
Drug interactions matter. Strong CYP3A4 inducers (for example, carbamazepine) can lower aripiprazole levels and reduce effect. Strong CYP3A4 or CYP2D6 inhibitors (like ketoconazole or fluoxetine) can raise levels and may need dose changes. Tell your prescriber about all medicines, including herbal products.
Take aripiprazole at the same time each day. You can take it with or without food. Don’t stop suddenly without talking to your doctor — doses are often tapered to avoid withdrawal or symptom return. If you’re pregnant, breastfeeding, or planning to become pregnant, discuss risks and benefits with your provider.
If you have questions about side effects, interactions, or monitoring, ask your prescriber or pharmacist. Avoid unverified online sellers and always use a licensed pharmacy. Small checks — regular weight, blood tests, and honest talks with your clinician — make this medicine safer and more effective.
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